VAMP-1/2/3 Polyclonal Antibody
Ucallm_WP14967-50
Price range: $268.00 through $328.00
Product details
Background:
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014],
Specifications
| Size | 50μL/100μL |
| Target | VAMP-1/2/3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 13kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VAMP-1/2/3. AA range:21-70 |
| Specificity | VAMP-1/2/3 Polyclonal Antibody detects endogenous levels of VAMP-1/2/3 protein. |
| Gene Name | VAMP1/VAMP2/VAMP3 |
| Protein Name | Vesicle-associated membrane protein 1/2/3 |
| Other Name | VAMP1; / SYB1; / Vesicle-associated membrane protein 1; / VAMP-1; / Synaptobrevin-1; / VAMP2; / SYB2; / Vesicle-associated membrane protein 2; / VAMP-2; / Synaptobrevin-2; / VAMP3; / SYB3; / Vesicle-associated membrane protein 3; / VAMP-3; / Cellubrevin; / CEB; / Synaptob |
| Species | Human |
| Gene ID | 6843;6844;9341 |
| Uniprot | P23763;P63027;Q15836, |
| Species.1 | Mouse |
| Gene ID.1 | 22317;22318;22319, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 25624;24803;29528 |
| Uniprot.2 | Q63666;P63045;P63025 |
| Cellular Localization | [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 2]: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein . |
| Tissue Expression | Nervous system, skeletal muscle and adipose tissue. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>SNARE interactions in vesicular transport |
| Function | Function:Involved in the targeting and/or fusion of transport vesicles to their target membrane.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subunit:Interacts with VAPA and VAPB.,tissue specificity:Nervous system, skeletal muscle and adipose tissue., |
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