SKU: WP14999 Categories: ,

VPAC1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14999-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

vasoactive intestinal peptide receptor 1(VIPR1) Homo sapiens This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Specifications

Size50μL/100μL
TargetVPAC1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)52kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human VIPR1. AA range:332-381
SpecificityVPAC1 Polyclonal Antibody detects endogenous levels of VPAC1 protein.
Gene NameVIPR1
Protein NameVasoactive intestinal polypeptide receptor 1
Other NameVIPR1; / Vasoactive intestinal polypeptide receptor 1; / VIP-R-1; / Pituitary adenylate cyclase-activating polypeptide type II receptor; / PACAP type II receptor; / PACAP-R-2; / PACAP-R2; / VPAC1
SpeciesHuman
Gene ID7433
UniprotP32241,
Species.1Mouse
Gene ID.122354
Uniprot.1P97751,
Species.2Rat
Gene ID.224875
Uniprot.2P30083
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionIn lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT.
Signaling_pathway
Research Areas>>Neuroactive ligand-receptor interaction
FunctionFunction:This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:In lung, HT29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and Tsup-1, but not in the T-cell lines PEER, MOLT-4, HSB and YT.,
Please login to post questions
Back to Top
Product has been added to your cart