SKU: WP4582 Categories: ,

VPS16 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP4582-100
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Product details

Background:

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],

Specifications

Size50μL/100μL
TargetVPS16
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)92kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human VPS16 AA range: 568-618
SpecificityThis antibody detects endogenous levels of VPS16 at Human/Mouse
Gene NameVPS16
Protein NameVPS16
Other Name
SpeciesHuman
Gene ID64601
UniprotQ9H269,
Species.1Mouse
Gene ID.1
Uniprot.1Q920Q4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationLate endosome membrane; Peripheral membrane protein; Cytoplasmic side . Lysosome membrane; Peripheral membrane protein; Cytoplasmic side . Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic vesicle, autophagosome . Colocalizes with AP-3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes. .
Tissue ExpressionUbiquitous.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal
Research Areas>>Salmonella infection
FunctionFunction:May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.,similarity:Belongs to the VPS16 family.,subcellular location:Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.,subunit:Large hetero-oligomeric complex together with VPS11, VPS18 and VPS33A. Interacts with STX7.,tissue specificity:Ubiquitous.,
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