VR1 rabbit pAb
Ucallm_WP17815-50
Price range: $268.00 through $328.00
Product details
Background:
transient receptor potential cation channel subfamily V member 1(TRPV1) Homo sapiens Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | VR1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 92kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human VR1 |
| Specificity | This antibody detects endogenous levels of VR1 at Human, Mouse,Rat |
| Gene Name | TRPV1 VR1 |
| Protein Name | VR1 |
| Other Name | Transient receptor potential cation channel subfamily V member 1; / TrpV1; / Capsaicin receptor; / Osm-9-like TRP channel 1; / OTRPC1; / Vanilloid receptor 1 |
| Species | Human |
| Gene ID | 7442 |
| Uniprot | Q8NER1, |
| Species.1 | Mouse |
| Gene ID.1 | 193034 |
| Uniprot.1 | Q704Y3, |
| Species.2 | Rat |
| Gene ID.2 | 83810 |
| Uniprot.2 | O35433 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell projection, dendritic spine membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . Mostly, but not exclusively expressed in postsynaptic dendritic spines. . |
| Tissue Expression | Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). |
| Signaling_pathway | Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Inflammatory mediator regulation of TRP channels |
| Function | Domain:The association domain (AD) is necessary for self-association.,enzyme regulation:Channel activity is activated via the interaction with PIRT and phosphatidylinositol-4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity.,Function:Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.,miscellaneous:Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.,PTM:Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 6 ANK repeats.,subunit:Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.,tissue specificity:Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level)., |
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