Name: WAVE3 Polyclonal Antibody
SKU: WP15011
Price: 268 USD
Availability: InStock

WAVE3 Polyclonal Antibody

Ucallm_WP15011-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15011-100

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Product details

Background:

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014],

Specifications

Size	50μL/100μL
Target	WAVE3
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human WASF3. AA range:151-200
Specificity	WAVE3 Polyclonal Antibody detects endogenous levels of WAVE3 protein.
Gene Name	WASF3
Protein Name	Wiskott-Aldrich syndrome protein family member 3
Other Name	WASF3; / KIAA0900; / SCAR3; / WAVE3; / Wiskott-Aldrich syndrome protein family member 3; / WASP family protein member 3; / Protein WAVE-3; / Verprolin homology domain-containing protein 3
Species	Human
Gene ID	10810
Uniprot	Q9UPY6,
Species.1	Mouse
Gene ID.1	245880
Uniprot.1	Q8VHI6
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm, cytoskeleton.
Tissue Expression	Expressed in ovary and brain.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis
Research Areas	>>Adherens junction; / >>Fc gamma R-mediated phagocytosis; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection; / >>Choline metabolism in cancer
Function	Domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,Function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subunit:Binds actin and the Arp2/3 complex.,tissue specificity:Expressed in ovary and brain.,