Product details
Background:
WDR40A rabbit pAb
Ucallm_WP8065-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DCAF12 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 50kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human WDR40A |
| Specificity | This antibody detects endogenous levels of WDR40A at Human, Mouse |
| Gene Name | DCAF12 KIAA1892 TCC52 WDR40A |
| Protein Name | DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A) |
| Other Name | |
| Species | Human |
| Gene ID | 25853 |
| Uniprot | Q5T6F0, |
| Species.1 | Mouse |
| Gene ID.1 | 68970 |
| Uniprot.1 | Q8BGZ3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . |
| Tissue Expression | Highly expressed in lung cancer tissues and some cancer cell lines (PubMed:18957058). Restricted expression in normal testis (PubMed:18957058). |
| Signaling_pathway | |
| Research Areas | |
| Function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation . Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy . |
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