SKU: WM0462 Categories: ,

WDR5 Monoclonal Antibody

Price range: $268.00 through $328.00

SKU: WM0462-50
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Product details

Background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetWDR5
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)37kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number19B2
ImmunogenPurified recombinant fragment of human WDR5 expressed in E. Coli.
SpecificityWDR5 Monoclonal Antibody detects endogenous levels of WDR5 protein.
Gene NameWDR5
Protein NameWD repeat-containing protein 5
Other NameWDR5; / BIG3; / WD repeat-containing protein 5; / BMP2-induced 3-kb gene protein
SpeciesHuman
Gene ID11091
UniprotP61964,
Species.1Mouse
Gene ID.1
Uniprot.1P61965
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus .
Tissue ExpressionEpithelium,Lung,Spleen,Uterus,
Signaling_pathway
Research Areas>>Cushing syndrome
FunctionFunction:Accelerates osteoblast differentiation.,similarity:Belongs to the WD repeat WDR5/wds family.,similarity:Contains 7 WD repeats.,subunit:Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Component of a multiprotein complex of 900 kDa containing WDR5.,
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