SKU: WP16874 Categories: ,

XPO6 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16874-100
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Product details

Background:

The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012],

Specifications

Size50μL/100μL
TargetXPO6
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)124kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human XPO6 AA range: 204-254
SpecificityThis antibody detects endogenous levels of XPO6 at Human/Mouse
Gene NameXPO6 KIAA0370 RANBP20
Protein NameXPO6
Other Name
SpeciesHuman
Gene ID23214
UniprotQ96QU8,
Species.1Mouse
Gene ID.174204
Uniprot.1Q924Z6
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm. .
Tissue Expression
Signaling_pathwayGenetic Information Processing >> Translation >> Nucleocytoplasmic transport
Research Areas>>Nucleocytoplasmic transport
FunctionFunction:Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.,similarity:Belongs to the exportin family.,similarity:Contains 1 importin N-terminal domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.,
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