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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/XRCC1 Polyclonal Antibody
SKU: WP15029 Categories: ,

XRCC1 Polyclonal Antibody

Ucallm_WP15029-50

Price range: $268.00 through $328.00

SKU: WP15029-100
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Product details

Background:

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

Specifications

TargetXRCC1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)70kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566
Sequence
SpecificityXRCC1 Polyclonal Antibody detects endogenous levels of XRCC1 protein.
Gene NameXRCC1
Protein NameDNA repair protein XRCC1
Other NameXRCC1; / DNA repair protein XRCC1; / X-ray repair cross-complementing protein 1
SpeciesHuman
Gene ID-17515
UniprotP18887,
Species.1Mouse
Gene ID-222594
Uniprot.1Q60596,
Species.2Rat
Gene ID-384495
Uniprot.2Q9ESZ0
Organism-4
Gene ID-4
SwissProt-4
BackgroundThe protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
Cellular LocalizationNucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
Tissue ExpressionExpressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
Signaling_pathway
Research Areas>>Base excision repair
FunctionFunction:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
RRID
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