Price range: $268.00 through $328.00
Background:
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
| Target | XRN2 |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 108kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human XRN2. AA range:81-130 |
| Sequence | |
| Specificity | XRN2 Polyclonal Antibody detects endogenous levels of XRN2 protein. |
| Gene Name | XRN2 |
| Protein Name | 5'-3' exoribonuclease 2 |
| Other Name | XRN2; / 5'-3' exoribonuclease 2; / DHM1-like protein; / DHP protein |
| Species | Human |
| Gene ID-1 | 22803 |
| Uniprot | Q9H0D6, |
| Species.1 | Mouse |
| Gene ID-2 | 24128 |
| Uniprot.1 | Q9DBR1 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a 5' -3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015], |
| Cellular Localization | Nucleus, nucleolus . |
| Tissue Expression | Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> RNA degradation |
| Research Areas | >>Ribosome biogenesis in eukaryotes; / >>RNA degradation |
| Function | Catalytic activity:Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.,Function:Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.,similarity:Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.,similarity:Contains 1 CCHC-type zinc finger.,tissue specificity:Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes., |
| RRID |
