Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
| Size | 50μL/100μL |
| Target | YMEL1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human YMEL1 AA range: 136-186 |
| Specificity | This antibody detects endogenous levels of YMEL1 at Human/Mouse/Rat |
| Gene Name | YME1L1 FTSH1 YME1L UNQ1868/PRO4304 |
| Protein Name | YMEL1 |
| Other Name | ATP-dependent zinc metalloprotease YME1L1; / ATP-dependent metalloprotease FtsH1; / Meg-4; / Presenilin-associated metalloprotease; / PAMP; / YME1-like protein 1 |
| Species | Human |
| Gene ID | 10730 |
| Uniprot | Q96TA2, |
| Species.1 | Mouse |
| Gene ID.1 | 27377 |
| Uniprot.1 | O88967, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q925S8 |
| Cellular Localization | Mitochondrion inner membrane . Mitochondrion . |
| Tissue Expression | High expression in cardiac and skeletal muscle mitochondria. |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Binds 1 zinc ion per subunit .,Function:Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family., |
