Price range: $268.00 through $328.00
Background:
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | ZCCHV |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 99kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 211-260 |
| Specificity | ZCCHV Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ZC3HAV1 ZC3HDC2 PRO1677 |
| Protein Name | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) |
| Other Name | |
| Species | Human |
| Gene ID | 56829 |
| Uniprot | Q7Z2W4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3UPF5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q8K3Y6 |
| Cellular Localization | [Isoform 1]: Cytoplasm . Nucleus . Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. .; [Isoform 2]: Cytoplasm . |
| Tissue Expression | Brain,Endometrium,Epithelium,Fetal liver,Kidney,Ovarian car |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The second and fourth zinc fingers are involved in binding to specific viral RNAs.,Function:Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 WWE domain.,similarity:Contains 4 C3H1-type zinc fingers.,subcellular location:Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.,subunit:Interacts with EXOSC5., |
