Price range: $268.00 through $328.00
Background:
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
| Size | 50μL/100μL |
| Target | ZIP1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC39A1. AA range:111-160 |
| Specificity | ZIP1 Polyclonal Antibody detects endogenous levels of ZIP1 protein. |
| Gene Name | SLC39A1 |
| Protein Name | Zinc transporter ZIP1 |
| Other Name | SLC39A1; / IRT1; / ZIP1; / ZIRTL; / CGI-08; / CGI-71; / Zinc transporter ZIP1; / Solute carrier family 39 member 1; / Zinc-iron-regulated transporter-like; / Zrt- and Irt-like protein 1; / ZIP-1; / hZIP1 |
| Species | Human |
| Gene ID | 27173 |
| Uniprot | Q9NY26, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QZ03 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. |
| Tissue Expression | Ubiquitous. Expressed in most adult and fetal tissues including the epidermis. |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease |
| Research Areas | >>Alzheimer disease; / >>Parkinson disease |
| Function | Function:Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.,miscellaneous:Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake.,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,subcellular location:Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.,tissue specificity:Ubiquitous. Expressed in most adult and fetal tissues including the epidermis., |
