Price range: $268.00 through $328.00
Background:
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014],
| Target | ZO1 |
| Reactivity | Human, Mouse, Pig |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 192kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | |
| Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000;IF 1:100-300;ELISA 1:5000-20000 |
| Composition | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein.AA1600-1700 |
| Sequence | |
| Specificity | ZO1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TJP1 ZO1 |
| Protein Name | Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) |
| Alias | |
| Organism-1 | Human |
| Gene ID-1 | 7082 |
| SwissProt-1 | Q07157 |
| Organism-2 | Mouse |
| Gene ID-2 | |
| SwissProt-2 | P39447 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, tight junction . Cell junction . Cell junction, gap junction. Cell projection, podosome . Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). . |
