PTEN Rabbit Monoclonal Antibody

Background：phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane

Elevate your tumor suppression and AKT/PKB signaling pathway research with the PTEN Rabbit Monoclonal Antibody (WR4121)—a Google-optimized, rigorously validated tool for specific PTEN detection. Tested across 14+ human, mouse, and rat cell lines (HL60, HCT116, A549, etc.), this antibody delivers clear, consistent banding (47 kDa predicted / 56 kDa observed) via 4-20% SDS-PAGE, paired with optimized conditions (4°C overnight incubation, 1:2500 dilution) and a robust Dylight 800-conjugated Goat anti-Rabbit detection system.

Ideal for studying PTEN’s roles as a key tumor suppressor, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, negative regulator of the AKT/PKB signaling pathway, or its long isoform’s association with the mitochondrial inner membrane—critical for cancer biology, phosphoinositide metabolism, and intracellular signal transduction research—this trusted PTEN Rabbit Monoclonal Antibody boosts assay reproducibility for oncology, tumor suppressor mechanism, and signal pathway studies. Order WR4121 today to advance your PTEN-focused experiments with a SEO-verified, high-performance research tool tailored for tumor suppression and AKT/PKB signaling research.