Stat2 Rabbit Monoclonal Antibody

Background：The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Elevate your cytokine signaling and interferon biology research with the Stat2 Rabbit Monoclonal Antibody (WR4116)—a Google-optimized, rigorously validated tool for specific Stat2 detection. Tested across 14+ human, mouse, and rat cell lines (HL60, HCT116, A549, etc.), this antibody delivers clear, consistent banding (98 kDa predicted / 113 kDa observed) via 4-20% SDS-PAGE, paired with optimized conditions (4°C overnight incubation, 1:2500 dilution) and a robust Dylight 800-conjugated Goat anti-Rabbit detection system.

Ideal for studying Stat2’s roles as a STAT family transcription factor, interferon (IFN)-mediated signaling (forming complexes with STAT1 and ISGF3G), transactivator function in IFN responses, its interaction with transcription adaptor P300/CBP, or adenovirus-mediated blocking of IFN-alpha responses—critical for immune signaling, viral immune evasion, and transcription regulation—this trusted Stat2 Rabbit Monoclonal Antibody boosts assay reproducibility for immunology, cytokine/growth factor signaling, and viral immunity research. Order WR4116 today to advance your Stat2-focused experiments with a SEO-verified, high-performance research tool tailored for interferon biology and cytokine signaling studies.