STAT5A Rabbit Monoclonal Antibody

Background：The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Elevate your cell signaling and cancer transcription research with the STAT5A Rabbit Monoclonal Antibody (WR4110)—a Google-optimized, rigorously validated tool for specific STAT5A detection. Tested across 14+ human, mouse, and rat cell lines (HL60, HCT116, A549, etc.), this antibody delivers perfect band alignment (91 kDa predicted/observed) via 4-20% SDS-PAGE, paired with optimized conditions (4°C overnight incubation, 1:5000 dilution) and a robust Dylight 800-conjugated Goat anti-Rabbit detection system.

Ideal for studying STAT5A’s roles as a STAT family transcription factor, cytokine/growth factor (IL2, IL3, GM-CSF, etc.)-mediated signal transduction, transcription activation, TEL/JAK2 fusion-driven tumorigenesis in myeloma/lymphoma, or its antiapoptotic function (regulating BCL2L1/BCL-X(L) expression), this trusted STAT5A Rabbit Monoclonal Antibody boosts assay reproducibility for immunology, oncology, and signal pathway research. Order WR4110 today to advance your STAT5A-focused experiments with a SEO-verified, high-performance research tool tailored for cell signaling and cancer transcription studies.