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Background:The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],

Specifications

Size	50μL/100μL
Target	GSK3β Phospho Ser9
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	46kD
MW(Observed)	46kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	phosphate
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0078R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	This antibody detects endogenous levels of GSK3β only when phosphorylated at Ser9.This antibody does not recognize phosphorylated at other sites.
Gene Name	GSK3B
Protein Name	Glycogen synthase kinase-3 beta
Other Name	GSK3B; / Glycogen synthase kinase-3 beta; / GSK-3 beta; / Serine/threonine-protein kinase GSK3B
Species	Human
Gene ID	2932
Uniprot	P49841,
Species.1	Mouse
Gene ID.1	56637
Uniprot.1	Q9WV60,
Species.2	Rat
Gene ID.2	84027
Uniprot.2	P18266
Cellular Localization	Cytoplasmic, Membranous
Tissue Expression	Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Basal cell carcinoma;Human Diseases >> Cancer: specific types >> Prostate cancer;Human Diseases >> Cancer: specific types >> Endometrial cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas	>>EGFR tyrosine kinase inhibitor resistance; / >>ErbB signaling pathway; / >>Chemokine signaling pathway; / >>Cell cycle; / >>mTOR signaling pathway; / >>PI3K-Akt signaling pathway; / >>Wnt signaling pathway; / >>Hedgehog signaling pathway; / >>Axon guidance; / >>Hippo signaling pathway; / >>Focal adhesion; / >>Signaling pathways regulating pluripotency of stem cells; / >>IL-17 signaling pathway; / >>T cell receptor signaling pathway; / >>B cell receptor signaling pathway; / >>Neurotrophin signaling pathway; / >>Dopaminergic synapse; / >>Insulin signaling pathway; / >>Melanogenesis; / >>Prolactin signaling pathway; / >>Thyroid hormone signaling pathway; / >>Insulin resistance; / >>Non-alcoholic fatty liver disease; / >>Cushing syndrome; / >>Growth hormone synthesis, secretion and action; / >>Alcoholic liver disease; / >>Alzheimer disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Yersinia infection; / >>Hepatitis C; / >>Measles; / >>Human cytomegalovirus infection; / >>Human papillomavirus infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Pathways in cancer; / >>Colorectal cancer; / >>Endometrial cancer; / >>Prostate cancer; / >>Basal cell carcinoma; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer; / >>Diabetic cardiomyopathy; / >>Lipid and atherosclerosis
Function	Catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,Function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,

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U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

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U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

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