Price range: $268.00 through $328.00
Background:The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010],
| Size | 50μL/100μL |
| Target | ATG16L1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 68kD |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0690R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | ATG16L1 |
| Protein Name | Autophagy-related protein 16-1 |
| Other Name | ATG16L1; / APG16L; / Autophagy-related protein 16-1; / APG16-like 1 |
| Species | Human |
| Gene ID | 695 |
| Uniprot | Q676U5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C0J2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm |
| Tissue Expression | Predominantly expressed in B-lymphocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway |
| Research Areas | >>NF-kappa B signaling pathway; / >>Osteoclast differentiation; / >>Platelet activation; / >>B cell receptor signaling pathway; / >>Fc epsilon RI signaling pathway; / >>Epstein-Barr virus infection; / >>Primary immunodeficiency |
| Function | Disease:Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10) [MIM:611081]. IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease.,Function:Plays an essential role in autophagy.,sequence Caution:Wrong choice of CDS.,similarity:Belongs to the WD repeat ATG16 family.,similarity:Contains 7 WD repeats.,subcellular location:Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.,subunit:Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa)., |
