Price range: $268.00 through $328.00
Background:
TCL1 belongs to the proto oncogene family. It promotes the nuclear translocation of AKT1 by activating the phosphorylation of AKT1, AKT2 and Akt3, so as to promote cell proliferation and survival and stabilize mitochondrial membrane potential. The encoded protein is involved in embryonic development, T cell carcinogenesis, pre lymphocyte carcinogenesis and B cell carcinogenesis.
| Size | 50μL/100μL |
| Target | TCL1 |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 13kD |
| MW(Observed) | 13kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM234 |
| Immunogen | Synthesized peptide derived from human TCL1 AA range: 50-114 |
| Specificity | The antibody can specifically recognize human TCL1 protein. |
| Gene Name | TCL1A TCL1 |
| Protein Name | TCL1 |
| Other Name | Anti TCL1A; / Lymphoma/leukemia, T-cell; / Oncogene TCL-1; / Oncogene TCL1; / P14 TCL1; / P14 TCL1 protein; / Protein p14 TCL1; / T cell leukemia 1; / T cell lymphoma 1; / T cell lymphoma 1A; / T-cell leukemia/lymphoma 1A; / T-cell leukemia/lymphoma protein 1A; / TCL 1 protein; / TCL1; / TCL1 oncogene; / TCL1 PEN; / Tcl1a; / TCL1A; / TCL1A_HUMAN |
| Species | Human |
| Gene ID | 8115 |
| Uniprot | P56279 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic, Nuclear |
| Tissue Expression | Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>PI3K-Akt signaling pathway |
| Function | Disease:Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14; 14)(q11; q32); translocation t(7; 14)(q35; q32); inversion inv(14)(q11; q32) that involves the T-cell receptor alpha/delta locuses.,Function:Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.,similarity:Belongs to the TCL1 family.,subcellular location:Microsomal fraction.,subunit:Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.,tissue specificity:Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation., |
