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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Myeloperoxidase [MPO] [PTR2562] mouse mAb
SKU: WM1360 Categories: ,

Myeloperoxidase [MPO] [PTR2562] mouse mAb

Ucallm_WM1360-50

Price range: $268.00 through $328.00

SKU: WM1360-50
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Product details

Background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

Specifications

Size50μL/100μL
TargetMyeloperoxidase
ReactivityHuman, Mouse, Rat
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)84kD
MW(Observed)70kD
Host SpeciesMouse
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMMR2562
ImmunogenSynthesized peptide derived from human Myeloperoxidase(MPO) AA range: 350-450
SpecificityThis antibody detects endogenous levels of MPO protein.
Gene NameMPO
Protein NameMyeloperoxidase
Other Name84 kDa myeloperoxidase antibody; / 89 kDa myeloperoxidase antibody; / EC1.11.2.2 antibody; / fj80f04 antibody; / MPO antibody; / mpx antibody; / myeloid-specific peroxidase antibody; / Myeloperoxidase antibody; / Myeloperoxidase heavy chain antibody; / Myeloperoxidase light chain antibody; / PERM_HUMAN antibody; / wu:fj80f04 antibody
SpeciesHuman
Gene ID4353
UniprotP05164,
Species.1Mouse
Gene ID.117523
Uniprot.1P11247,
Species.2Rat
Gene ID.2
Uniprot.2D3ZGE2
Cellular LocalizationCytoplasmic
Tissue ExpressionLeukemia,Leukocyte,Liver,Plasma,Saliva
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia
Research Areas>>Drug metabolism - other enzymes; / >>Phagosome; / >>Neutrophil extracellular trap formation; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia
FunctionPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
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