Price range: $268.00 through $328.00
Background:
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Dkk-1 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 29kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 8E9 |
| Immunogen | Purified recombinant fragment of Dkk-1 expressed in E. Coli. |
| Specificity | Dkk-1 Monoclonal Antibody detects endogenous levels of Dkk-1 protein. |
| Gene Name | DKK1 |
| Protein Name | Dickkopf-related protein 1 |
| Other Name | DKK1; / Dickkopf-related protein 1; / Dickkopf-1; / Dkk-1; / hDkk-1; / SK |
| Species | Human |
| Gene ID | 22943 |
| Uniprot | O94907, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O54908 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Placenta. |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | >>Wnt signaling pathway; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases |
| Function | Function:Inhibitor of Wnt signaling pathway.,similarity:Belongs to the dickkopf family.,tissue specificity:Placenta., |
