SKU: WM0628 Categories: ,

Syntenin mouse mAb

Price range: $268.00 through $328.00

SKU: WM0628-50
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Product details

Background:
syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Specifications

Specification50μL;100μL
TargetSyntenin
ReactivityHuman
ApplicationsWB
MW(Calculated)
MW(Observed)32kD
Host SpeciesMouse
Isotype
Conjugate
ModificationUnmodified
Recommended Dilution RatioWB 1:1000
CompositionLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification ProcessThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Puity
Storage Condition-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenPurified recombinant human Syntenin protein fragments expressed in E.coli.
Sequence
SpecificityThis antibody detects endogenous levels of Syntenin and does not cross-react with related proteins.
Gene Namesdcbp
Protein Name
AliasMDA-9;MDA9;Melanoma differentiation-associated protein 9;Pro-TGF-alpha cytoplasmic domain-interacting protein 18;Scaffold protein Pbp1;SDCB1_HUMAN;Sdcbp;SDCBP;ST1;SYCL;Syndecan binding protein;syntenin;Syndecan binding protein 1;Syndecan-binding protein 1;Syntenin 1;Syntenin-1;TACIP18.
Organism-1Human
Gene ID-16386
SwissProt-1O00560
Organism-2Mouse
Gene ID-2
SwissProt-2O08992
Organism-3
Gene ID-3
SwissProt-3
Organism-4
Gene ID-4
SwissProt-4
Cellular LocalizationCell junction, focal adhesion . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus . Melanosome . Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Secreted, extracellular exosome . Membrane raft . Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4, 5-bisphosphate (PIP2) (PubMed:27386966). .
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