Price range: $268.00 through $328.00
Background:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Msi1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 39kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 5A4 |
| Immunogen | Purified recombinant human Musashi-1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of Musashi-1 and does not cross-react with related proteins. |
| Gene Name | msi1 |
| Protein Name | |
| Other Name | MSI1; / Musashi-1; / Msi 1; / Msi1; / MSI1H_HUMAN; / Musashi homolog 1; / Musashi-1; / Musashi1; / RNA binding protein Musashi homolog 1; / RNA-binding protein Musashi homolog 1. |
| Species | Human |
| Gene ID | 4440 |
| Uniprot | O43347, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61474 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. |
| Signaling_pathway | |
| Research Areas | >>mRNA surveillance pathway |
| Function | Domain:The first RNA recognition motif binds more strongly to RNA compared to the second one.,Function:RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,tissue specificity:Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines., |
