Product details

Background:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],

Specifications

Size	50μL/100μL
Target	cIAP2
Reactivity	Human, Monkey
Applications	WB
MW(Calculated)
MW(Observed)	72kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	12E2
Immunogen	Purified recombinant human c-IAP2 protein fragments expressed in E.coli
Specificity	This antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.
Gene Name	birc3
Protein Name
Other Name	AIP 1; / AIP1; / API 2; / API2; / API2; / Apoptosis inhibitor 2; / Baculoviral IAP repeat containing 3; / Baculoviral IAP repeat containing protein 3; / Baculoviral IAP repeat-containing protein 3; / BIRC 3; / BIRC3; / BIRC3; / BIRC3_HUMAN; / C IAP2; / C-IAP2; / CIAP 2; / CIAP 2; / CIAP2; / HAIP 1; / HAIP1; / HAIP1; / HIAP 1; / HIAP-1; / HIAP1; / IAP homolog C; / IAP-1; / Inhibitor of apoptosis protein 1; / Inhibitor of apoptosis protein 1; / MALT 2; / MALT2; / Mammalian IAP homolog C; / MIHC; / MIHC; / RING finger protein 49; / RNF49; / TNFR2 TRAF signaling complex protein 1; / TNFR2 TRAF signalling complex protein; / TNFR2-TRAF-signaling complex protein 1.
Species	Human
Gene ID	330
Uniprot	Q13489,
Species.1	Mouse
Gene ID.1
Uniprot.1	O08863
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Nucleus .
Tissue Expression	Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
Research Areas	>>Platinum drug resistance; / >>NF-kappa B signaling pathway; / >>Ubiquitin mediated proteolysis; / >>Apoptosis; / >>Apoptosis - multiple species; / >>Necroptosis; / >>Hippo signaling pathway; / >>Focal adhesion; / >>NOD-like receptor signaling pathway; / >>TNF signaling pathway; / >>Salmonella infection; / >>Toxoplasmosis; / >>Herpes simplex virus 1 infection; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Small cell lung cancer
Function	Disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11; 18)(q21; q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,Function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.,

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cIAP2 mouse mAb

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cIAP2 mouse mAb

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