SKU: WN0203 Categories: ,

Recombinant CD235a Fc-Fused Nanobody (VF0071)

$365.00

SKU: WN0203
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Product details

Background:Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]

Specifications

Size100μL
TargetGlycophorin A
ReactivityHuman
ApplicationsELISA
MW(Calculated)
MW(Observed)
Host Species
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioELISA 1:5000-100000
FormulationPhosphate-buffered solution
PurificationRecombinant Expression and Affinity purified
Storage-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
ConcentrationPlease check the information on the tube
Clonality
Clone NumberVF0071
ImmunogenPurified recombinant Human CD235a
SpecificityThis recombinant monoclonal antibody can detects endogenous levels of CD235a protein.
Gene NameGYPA GPA
Protein NameGlycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)
Other NameGYPA; / GPA; / Glycophorin-A; / MN sialoglycoprotein; / PAS-2; / Sialoglycoprotein alpha; / CD235a; / CD235a nanobody
SpeciesHuman
Gene ID2993
UniprotP02724
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type I membrane protein . Appears to be colocalized with SLC4A1.
Tissue ExpressionBlood,Bone marrow,Kidney,Liver,Lung,Miltenberger class V
Signaling_pathwayOrganismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas
FunctionGlycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virus.,online information:Blood group antigen gene mutation database,polymorphism:Along with GYPB, GYPA is responsible for the MNS blood group system.,similarity:Belongs to the glycophorin A family.,
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