Name: U-Blot® A20 Rabbit mAb
SKU: WR4957
Price: 268 USD
Availability: InStock

U-Blot® A20 Rabbit mAb

Ucallm_WR4957-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR4957-50

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Product details

Background:This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012],

Specifications

Size	50μL/100μL
Target	A20
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	90kD
MW(Observed)	82kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1180R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	TNFAIP3
Protein Name	Tumor necrosis factor alpha-induced protein 3
Other Name	TNFAIP3; / OTUD7C; / Tumor necrosis factor alpha-induced protein 3; / TNF alpha-induced protein 3; / OTU domain-containing protein 7C; / Putative DNA-binding protein A20; / Zinc finger protein A20
Species	Human
Gene ID	7128
Uniprot	P21580
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm. Nucleus. Lysosome.; [A20p50]: Cytoplasm.
Tissue Expression	Epithelium,Testis,Trachea,
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>NF-kappa B signaling pathway; / >>Necroptosis; / >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>TNF signaling pathway; / >>Measles; / >>Epstein-Barr virus infection
Function	Function:Interacts with NAF1 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system and may contribute to the in vivo effects of TNF (By similarity). Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains.,induction:By TNF-alpha.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 7 A20-type zinc fingers.,subunit:Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2.,