Name: SIR4 Polyclonal Antibody
SKU: WP1340
Price: 268 USD
Availability: InStock

SIR4 Polyclonal Antibody

Ucallm_WP1340-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP1340-100

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Product details

Background:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008],

Specifications

Target	SIR4
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	34kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 30-110
Sequence
Specificity	SIR4 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	SIRT4 SIR2L4
Protein Name	NAD-dependent protein deacetylase sirtuin-4 (NAD-dependent ADP-ribosyltransferase sirtuin-4) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Other Name
Species	Human
Gene ID-1	23409
Uniprot	Q9Y6E7,
Species.1	Mouse
Gene ID-2
Uniprot.1	Q8R216
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008],
Cellular Localization	Mitochondrion matrix .
Tissue Expression	Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.
Signaling_pathway
Research Areas	>>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways
Function	Catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,Function:Probable NAD-dependent deacetylase.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,tissue specificity:Widely expressed. Weakly expressed in leukocytes and fetal thymus.,
RRID