Price range: $268.00 through $328.00
Background:
This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
| Size | 50μL/100μL |
| Target | SREK1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SREK1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SREK1 SFRS12 SRRP86 |
| Protein Name | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) |
| Other Name | |
| Species | Human |
| Gene ID | 140890 |
| Uniprot | Q8WXA9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BZX4, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9JKL7 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Brain,Lung,Lymph node,Mammary gland,Pancrea |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome (By similarity). Interacts with P18SRP., |
