Product details
Background:
DOCK8 rabbit pAb
Ucallm_WP6390-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DOCK8 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 231kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DOCK8 |
| Specificity | This antibody detects endogenous levels of DOCK8 at Human, Mouse |
| Gene Name | DOCK8 |
| Protein Name | Dedicator of cytokinesis protein 8 |
| Other Name | |
| Species | Human |
| Gene ID | 81704 |
| Uniprot | Q8NF50, |
| Species.1 | Mouse |
| Gene ID.1 | 76088 |
| Uniprot.1 | Q8C147 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side . Enriched and co-localizes with GTPase CDC42 at the immunological synapse formed during T cell/antigen presenting cell cognate interaction. Translocates from the cytoplasm to the plasma membrane in response to chemokine CXCL12/SDF-1-alpha stimulation. . |
| Tissue Expression | Expressed in peripheral blood mononuclear cells (PBMCs). |
| Signaling_pathway | |
| Research Areas | |
| Function | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP . During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane . Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing . |
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