Price range: $268.00 through $328.00
Background:
This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013],
| Size | 50μL/100μL |
| Target | COL14A1 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 194kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human N-ternal Collagen XIV alpha1. AA range:71-120 |
| Specificity | COL14A1 Polyclonal Antibody detects endogenous levels of COL14A1 protein. |
| Gene Name | COL14A1 |
| Protein Name | Collagen alpha-1(XIV) chain |
| Other Name | COL14A1; / UND; / Collagen alpha-1; / XIV; / chain; / Undulin |
| Species | Human |
| Gene ID | 7373 |
| Uniprot | Q05707, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q80X19 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . |
| Tissue Expression | Brain,Liver,Muscle,PNS,Testis, |
| Signaling_pathway | |
| Research Areas | >>Protein digestion and absorption |
| Function | Function:Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.,PTM:Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.,PTM:May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 2 VWFA domains.,similarity:Contains 8 fibronectin type-III domains.,subunit:Homotrimer., |
