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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/CtBP1 Polyclonal Antibody
SKU: WP11828 Categories: ,

CtBP1 Polyclonal Antibody

Ucallm_WP11828-50

Price range: $268.00 through $328.00

SKU: WP11828-100
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Product details

Background:

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCtBP1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)48kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CtBP1. AA range:388-437
SpecificityCtBP1 Polyclonal Antibody detects endogenous levels of CtBP1 protein.
Gene NameCTBP1
Protein NameC-terminal-binding protein 1
Other NameCTBP1; / CTBP; / C-terminal-binding protein 1; / CtBP1
SpeciesHuman
Gene ID1487
UniprotQ13363,
Species.1Mouse
Gene ID.113016
Uniprot.1O88712,
Species.2Rat
Gene ID.229382
Uniprot.2Q9Z2F5
Cellular LocalizationCytoplasm . Nucleus .
Tissue ExpressionExpressed in germinal center B-cells.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Notch signaling pathway
Research Areas>>Wnt signaling pathway; / >>Notch signaling pathway; / >>Pathways in cancer; / >>Chronic myeloid leukemia
Functioncofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change.,Function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.,PTM:ADP-ribosylated; when cells are exposed to brefeldin-A (BFA).,PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.,PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with FOXP2, HDAC4, HDAC5 and HDAC9. Interacts with GLIS2 but not GLIS1 or GLIS3 (By similarity). Interacts with FOXP1, HIPK2, PNN and NRIP1. Interacts with ZFHX1B and WIZ. Interacts with Epstein-Barr virus EBNA3 and EBNA6.,
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