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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Endoplasmin Polyclonal Antibody
SKU: WP12186 Categories: ,

Endoplasmin Polyclonal Antibody

Ucallm_WP12186-50

Price range: $268.00 through $328.00

SKU: WP12186-100
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Product details

Background:

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012],

Specifications

Size50μL/100μL
TargetEndoplasmin
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)92kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human GRP94. AA range:754-803
SpecificityEndoplasmin Polyclonal Antibody detects endogenous levels of Endoplasmin protein.
Gene NameHSP90B1
Protein NameEndoplasmin
Other NameHSP90B1; / GRP94; / TRA1; / Endoplasmin; / 94 kDa glucose-regulated protein; / GRP-94; / Heat shock protein 90 kDa beta member 1; / Tumor rejection antigen 1; / gp96 homolog
SpeciesHuman
Gene ID7184
UniprotP14625,
Species.1Mouse
Gene ID.122027
Uniprot.1P08113
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Tissue ExpressionBlood,Brain,Liver,Lung,Platelet,Skin,
Signaling_pathwayOrganismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Prostate cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas>>Protein processing in endoplasmic reticulum; / >>PI3K-Akt signaling pathway; / >>IL-17 signaling pathway; / >>Estrogen signaling pathway; / >>Thyroid hormone synthesis; / >>Salmonella infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Prostate cancer; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis
FunctionFunction:Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity.,PTM:Phosphorylated.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.,
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