Price range: $268.00 through $328.00
Background:
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016],
| Size | 50μL/100μL |
| Target | KANK2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 91kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KANK2. AA range:351-400 |
| Specificity | KANK2 Polyclonal Antibody detects endogenous levels of KANK2 protein. |
| Gene Name | KANK2 |
| Protein Name | KN motif and ankyrin repeat domain-containing protein 2 |
| Other Name | KANK2; / ANKRD25; / KIAA1518; / MXRA3; / SIP; / KN motif and ankyrin repeat domain-containing protein 2; / Ankyrin repeat domain-containing protein 25; / Matrix-remodeling-associated protein 3; / SRC-1-interacting protein; / SIP; / SRC-interacting protein; / SRC |
| Species | Human |
| Gene ID | 25959 |
| Uniprot | Q63ZY3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BX02 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Mitochondrion . |
| Tissue Expression | Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 5 ANK repeats.,tissue specificity:Strongly expressed in cervix, colon, heart, kidney and lung., |
