Name: Rev-erbα Polyclonal Antibody
SKU: WP14259
Price: 268 USD
Availability: InStock

Rev-erbα Polyclonal Antibody

Ucallm_WP14259-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP14259-100

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Product details

Background:

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013],

Specifications

Size	50μL/100μL
Target	NR1D1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC
MW(Calculated)
MW(Observed)	67kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from Rev-erbα . at AA range: 350-430
Specificity	Rev-erbα Polyclonal Antibody detects endogenous levels of Rev-erbα protein.
Gene Name	NR1D1
Protein Name	Nuclear receptor subfamily 1 group D member 1
Other Name	NR1D1; / EAR1; / HREV; / THRAL; / Nuclear receptor subfamily 1 group D member 1; / Rev-erbA-alpha; / V-erbA-related protein 1; / EAR-1
Species	Human
Gene ID	9572
Uniprot	P20393,
Species.1	Mouse
Gene ID.1	217166
Uniprot.1	Q3UV55,
Species.2	Rat
Gene ID.2	252917
Uniprot.2	Q63503
Cellular Localization	Nucleus . Cytoplasm . Cell projection, dendrite . Cell projection, dendritic spine . Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization. .
Tissue Expression	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines.
Signaling_pathway	Organismal Systems >> Environmental adaptation >> Circadian rhythm
Research Areas	>>Circadian rhythm
Function	Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with C1D.,tissue specificity:Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.,

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Rev-erbα Polyclonal Antibody

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Rev-erbα Polyclonal Antibody

Product details

Specifications

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