Name: Sgo2 Polyclonal Antibody
SKU: WP14463
Price: 268 USD
Availability: InStock

Sgo2 Polyclonal Antibody

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Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP14463-100

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Product details

Background:

function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the shugoshin family., subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase., subunit:Directly interacts with PPP2CA.,

Specifications

Target	Sgo2
Reactivity	Human, Mouse
Applications	IHC, IF, ELISA
MW(Calculated)	145kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate
Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Composition	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification Process	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage Condition	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human SGOL2. AA range:681-730
Sequence
Specificity	Sgo2 Polyclonal Antibody detects endogenous levels of Sgo2 protein.
Gene Name	SGOL2
Protein Name	Shugoshin-like 2
Alias	SGOL2;Shugoshin-like 2;Shugoshin-2;Sgo2;Tripin
Organism-1	Human
Gene ID-1	151246
SwissProt-1	Q562F6
Organism-2	Mouse
Gene ID-2
SwissProt-2	Q7TSY8
Organism-3
Gene ID-3
SwissProt-3
Organism-4
Gene ID-4
SwissProt-4
Cellular Localization	Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487). Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487). .