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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ZP2 Polyclonal Antibody
SKU: WP15100 Categories: ,

ZP2 Polyclonal Antibody

Ucallm_WP15100-50

Price range: $268.00 through $328.00

SKU: WP15100-100
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Product details

Background:

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Specifications

Size50μL/100μL
TargetZP2
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)82kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human ZP2.
SpecificityZP2 Polyclonal Antibody detects endogenous levels of ZP2 protein.
Gene NameZP2
Protein NameZona pellucida sperm-binding protein 2
Other NameZP2; / ZPA; / Zona pellucida sperm-binding protein 2; / Zona pellucida glycoprotein 2; / Zp-2; / Zona pellucida protein A
SpeciesHuman
Gene ID7783
UniprotQ05996,
Species.1Mouse
Gene ID.1
Uniprot.1P20239
Species.2
Gene ID.2
Uniprot.2
Cellular Localization[Processed zona pellucida sperm-binding protein 2]: Zona pellucida .; Cell membrane; Single-pass type I membrane protein .
Tissue ExpressionExpressed in occytes(at protein level).
Signaling_pathway
Research Areas
Functiondevelopmental stage:Expressed during the 2-week growth phase of oogenesis, prior to ovulation.,Domain:The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.,Function:The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.,PTM:O-glycosylated; contains sulfate-substituted glycans.,PTM:Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.,PTM:Proteolytically cleaved in the N-terminal part after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy.,similarity:Belongs to the ZP domain family. ZPA subfamily.,similarity:Contains 1 ZP domain.,subunit:Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.,tissue specificity:Oocytes.,
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