Name: SPTLC1 Polyclonal Antibody
SKU: WP15305
Price: 268 USD
Availability: InStock

SPTLC1 Polyclonal Antibody

Ucallm_WP15305-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15305-100

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Product details

Background:

This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013],

Specifications

Size	50μL/100μL
Target	SPTLC1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	52kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from SPTLC1 . at AA range: 411-460
Specificity	SPTLC1 Polyclonal Antibody detects endogenous levels of SPTLC1 protein.
Gene Name	SPTLC1
Protein Name	Serine palmitoyltransferase 1
Other Name	SPTLC1; / LCB1; / Serine palmitoyltransferase 1; / Long chain base biosynthesis protein 1; / LCB 1; / Serine-palmitoyl-CoA transferase 1; / SPT 1; / SPT1
Species	Human
Gene ID	10558
Uniprot	O15269,
Species.1	Mouse
Gene ID.1	268656
Uniprot.1	O35704
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endoplasmic reticulum membrane; Single-pass membrane protein .
Tissue Expression	Widely expressed. Not detected in small intestine.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway
Research Areas	>>Sphingolipid metabolism; / >>Metabolic pathways; / >>Sphingolipid signaling pathway
Function	Catalytic activity:Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).,cofactor:Pyridoxal phosphate.,Disease:Defects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1 (HSAN1) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1 is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.,subunit:SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme.,tissue specificity:Widely expressed. Not detected in small intestine.,