SKU: WP15863 Categories: ,

CD303 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15863-100
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Product details

Background:

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD303
ReactivityHuman
ApplicationsIHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthetic peptide from human protein at AA range: 91-140
SpecificityThe antibody detects endogenous CD303
Gene NameCLEC4C BDCA2 CLECSF11 CLECSF7 DLEC HECL UNQ9361/PRO34150
Protein NameC-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303)
Other NameC-type lectin domain family 4 member C; / Blood dendritic cell antigen 2; / BDCA-2; / C-type lectin superfamily member 7; / Dendritic lectin; / CD antigen CD303
SpeciesHuman
Gene ID170482
UniprotQ8WTT0
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass type II membrane protein .
Tissue ExpressionExpressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
Signaling_pathway
Research Areas
FunctionFunction:Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.,online information:BDCA-2,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.,
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