The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008],
Specifications
Size
50μL/100μL
Target
GKN1
Reactivity
Human, Mouse
Applications
WB
MW(Calculated)
22kD
MW(Observed)
Host Species
Rabbit
Isotype
IgG
Conjugate/Modification
Unmodified
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human GKN1 AA range: 47-97
Specificity
This antibody detects endogenous levels of GKN1 at Human/Mouse
Gene Name
GKN1 AMP18 CA11 UNQ489/PRO1005
Protein Name
GKN1
Other Name
Species
Human
Gene ID
56287
Uniprot
Q9NS71,
Species.1
Mouse
Gene ID.1
66283
Uniprot.1
Q9CR36
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Secreted . Cytoplasmic granule . Golgi apparatus . Shows abundant granular cytoplasmic staining, with perinuclear accentuation suggestive of the Golgi apparatus. .
Tissue Expression
Expressed in stomach (at protein level). No expression is detected in cancer tissue or gastric cancer cell lines.
Signaling_pathway
Research Areas
Function
Caution:It is uncertain whether Met-1 or Met-15 is the initiator.,Function:Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.,similarity:Belongs to the gastrokine family.,similarity:Contains 1 BRICHOS domain.,tissue specificity:Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.,