Background：Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Looking for a high-specificity Phospho-Histone H3 (Thr3) Rabbit Monoclonal Antibody (WR4071) for chromatin structure, nucleosome, or histone modification research? Our WR4071 antibody delivers exceptional value: it’s validated across 14+ human/mouse/rat cell lines (HL60, HUVEC, HCT116 & more), optimized for 4-20% SDS-PAGE, and works at a cost-efficient 1:5000 dilution (incubated 4°C overnight, detected via Dylight 800-conjugated secondary antibody). Critically, it hits the perfect 15 kDa predicted/observed band—ideal for studying Histone H3 Thr3 phosphorylation dynamics.
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