Name: ABC3H Polyclonal Antibody
SKU: WP1069
Price: 268 USD
Availability: InStock

ABC3H Polyclonal Antibody

Ucallm_WP1069-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP1069-100

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Product details

Background:

This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],

Specifications

Size	50μL/100μL
Target	ABC3H
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	22kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	ABC3H Polyclonal Antibody detects endogenous levels of protein.
Gene Name	APOBEC3H
Protein Name	DNA dC->dU-editing enzyme APOBEC-3H (APOBEC-related protein 10) (ARP-10) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H)
Other Name
Species	Human
Gene ID	164668
Uniprot	Q6NTF7
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus. Cytoplasm. Cytoplasm, P-body. Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
Tissue Expression	Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
Signaling_pathway
Research Areas	>>Viral life cycle - HIV-1; / >>Human immunodeficiency virus 1 infection
Function	cofactor:Zinc.,Function:Poorly expressed deaminase that is ineffective at inhibiting retroviral replication. Has DNA deaminase (cytidine deaminase) activity but is not able to mediate G-to-A hypermutation in newly synthesized retroviral DNA.,miscellaneous:APOBEC3H from old world monkeys has retained its antiviral activity, while it is lost in other primates.,miscellaneous:It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Present at low level in 293T cells. Unstable protein, suggesting that it may be degraded by the proteasome (at protein level). Weakly expressed. Expressed in testis, ovary, fetal liver and skin.,

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ABC3H Polyclonal Antibody

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ABC3H Polyclonal Antibody

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