ACAD-9 Polyclonal Antibody
Ucallm_WP10905-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010],
Specifications
| Size | 50μL/100μL |
| Target | ACAD-9 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 69kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from ACAD-9 . at AA range: 530-610 |
| Specificity | ACAD-9 Polyclonal Antibody detects endogenous levels of ACAD-9 protein. |
| Gene Name | ACAD9 |
| Protein Name | Acyl-CoA dehydrogenase family member 9 mitochondrial |
| Other Name | ACAD9; / Acyl-CoA dehydrogenase family member 9; / mitochondrial; / ACAD-9 |
| Species | Human |
| Gene ID | 28976 |
| Uniprot | Q9H845, |
| Species.1 | Mouse |
| Gene ID.1 | 229211 |
| Uniprot.1 | Q8JZN5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side . Essentially associated with membranes. . |
| Tissue Expression | Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver (PubMed:12359260). In the cerebellum uniquely expressed in the granular layer (at protein level) (PubMed:21237683). |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:FAD.,Disease:Defects in ACAD9 are a cause of acyl-CoA dehydrogenase family member type 9 deficiency (ACAD9 deficiency) [MIM:611126]. ACAD9 deficiency patients present with episodic liver dysfunction during otherwise mild illnesses or cardiomyopathy, along with chronic neurologic dysfunction.,Function:Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA then on stearoyl-CoA. Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0).,similarity:Belongs to the acyl-CoA dehydrogenase family.,tissue specificity:Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver., |
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