ACADL rabbit pAb
Ucallm_WP16364-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ACADL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 47kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ACADL AA range: 258-308 |
| Specificity | This antibody detects endogenous levels of ACADL at Human/Mouse/Rat |
| Gene Name | ACADL |
| Protein Name | ACADL |
| Other Name | |
| Species | Human |
| Gene ID | 33 |
| Uniprot | P28330, |
| Species.1 | Mouse |
| Gene ID.1 | 11363 |
| Uniprot.1 | P51174, |
| Species.2 | Rat |
| Gene ID.2 | 25287 |
| Uniprot.2 | P15650 |
| Cellular Localization | Mitochondrion matrix . |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>Fatty acid degradation; / >>Metabolic pathways; / >>Fatty acid metabolism; / >>PPAR signaling pathway |
| Function | Catalytic activity:Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.,cofactor:FAD.,Disease:Impaired ACADL activity results in non-ketotic hypoglycemia, hypotonia, muscle weakness and episodes of cardiorespiratory arrest associated with fasting [MIM:201460].,miscellaneous:A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.,pathway:Lipid metabolism; mitochondrial fatty acid beta-oxidation.,similarity:Belongs to the acyl-CoA dehydrogenase family.,subunit:Homotetramer., |
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