Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010],
| Size | 50μL/100μL |
| Target | AChRα5 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AChRalpha5. AA range:166-215 |
| Specificity | AChRα5 Polyclonal Antibody detects endogenous levels of AChRα5 protein. |
| Gene Name | CHRNA5 |
| Protein Name | Neuronal acetylcholine receptor subunit alpha-5 |
| Other Name | CHRNA5; / NACHRA5; / Neuronal acetylcholine receptor subunit alpha-5 |
| Species | Human |
| Gene ID | 1138 |
| Uniprot | P30532, |
| Species.1 | Mouse |
| Gene ID.1 | 110835 |
| Uniprot.1 | Q2MKA5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P20420 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Eye, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction |
| Function | Disease:Genetic variations in CHRNA5 may be associated with susceptibility to lung cancer type 2 (LNCR2) [MIM:612052].,Function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta)., |
