Name: U-Blot® ACSL4 Rabbit mAb
SKU: WR4261
Price: 268 USD
Availability: InStock

U-Blot® ACSL4 Rabbit mAb

Western blot analysis of lysates from Hela cells, using ACSL4 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody ( ) was used to detect the antibody.

WR4261 Western blot analysis of lysates from Hela cells, using ACSL4 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4261-50

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Product details

Background:The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]

Specifications

Size	50μL/100μL
Target	ACSL4
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	78kD
MW(Observed)	78kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:2000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0448R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ACSL4 ACS4 FACL4 LACS4
Protein Name	ACSL4
Other Name	Long-chain-fatty-acid--CoA ligase 4; / Long-chain acyl-CoA synthetase 4; / LACS 4
Species	Human
Gene ID	2182
Uniprot	O60488,
Species.1	Mouse
Gene ID.1	50790
Uniprot.1	Q9QUJ7,
Species.2	Rat
Gene ID.2	113976
Uniprot.2	O35547
Cellular Localization	Membrane
Tissue Expression
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Peroxisome;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas	>>Fatty acid biosynthesis; / >>Fatty acid degradation; / >>Metabolic pathways; / >>Fatty acid metabolism; / >>PPAR signaling pathway; / >>Peroxisome; / >>Ferroptosis; / >>Thermogenesis; / >>Adipocytokine signaling pathway
Function