SKU: WP2319 Categories: ,

ADAM8 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2319-100
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Product details

Background:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009],

Specifications

TargetADAM8
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)90kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
Sequence
SpecificityADAM8 Polyclonal Antibody detects endogenous levels of protein.
Gene NameADAM8 MS2
Protein NameDisintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (Cell surface antigen MS2) (CD antigen CD156a)
Other Name
SpeciesHuman
Gene ID-1101
UniprotP78325,
Species.1Mouse
Gene ID-2
Uniprot.1Q05910
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009],
Cellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue ExpressionExpressed on neutrophils and monocytes.
Signaling_pathway
Research Areas
Functioncofactor:Binds 1 zinc ion per subunit.,Function:Possible involvement in extravasation of leukocytes.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed on neutrophils and monocytes.,
RRID
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