Name: ADCY5 rabbit pAb
SKU: WP17306
Price: 268 USD
Availability: InStock

Product details

Background:

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

Specifications

Size	50μL/100μL
Target	ADCY5
Reactivity	Human, Mouse, Rat
Applications	WB
MW(Calculated)	139kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human ADCY5 AA range: 471-521
Specificity	This antibody detects endogenous levels of ADCY5 at Human/Mouse/Rat
Gene Name	ADCY5
Protein Name	ADCY5
Other Name
Species	Human
Gene ID	111
Uniprot	O95622,
Species.1	Mouse
Gene ID.1	224129
Uniprot.1	P84309,
Species.2	Rat
Gene ID.2	64532
Uniprot.2	Q04400
Cellular Localization	Cell membrane; Multi-pass membrane protein. Cell projection, cilium .
Tissue Expression	Detected in pancreas islets (at protein level). Detected in pancreas islets.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> GnRH signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>Purine metabolism; / >>Metabolic pathways; / >>Endocrine resistance; / >>Rap1 signaling pathway; / >>cGMP-PKG signaling pathway; / >>cAMP signaling pathway; / >>Chemokine signaling pathway; / >>Phospholipase D signaling pathway; / >>Oocyte meiosis; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Adrenergic signaling in cardiomyocytes; / >>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Gap junction; / >>Platelet activation; / >>Circadian entrainment; / >>Thermogenesis; / >>Retrograde endocannabinoid signaling; / >>Glutamatergic synapse; / >>Cholinergic synapse; / >>Serotonergic synapse; / >>GABAergic synapse; / >>Dopaminergic synapse; / >>Inflammatory mediator regulation of TRP channels; / >>Insulin secretion; / >>GnRH signaling pathway; / >>Ovarian steroidogenesis; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Melanogenesis; / >>Thyroid hormone synthesis; / >>Oxytocin signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Renin secretion; / >>Aldosterone synthesis and secretion; / >>Relaxin signaling pathway; / >>Cortisol synthesis and secretion; / >>Parathyroid hormone synthesis, secretion and action; / >>Cushing syndrome; / >>Growth hormone synthesis, secretion and action; / >>Salivary secretion; / >>Gastric acid secretion; / >>Pancreatic secretion; / >>Bile secretion; / >>Parkinson disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Morphine addiction; / >>Alcoholism; / >>Human cytomegalovirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Dilated cardiomyopathy
Function	Catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,Function:This is a membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

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ADCY5 rabbit pAb

Product details

Specifications

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ADCY5 rabbit pAb

Product details

Specifications

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