Product details
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Advillin rabbit pAb
Ucallm_WP7792-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | AVIL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 90kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Advillin |
| Specificity | This antibody detects endogenous levels of Advillin at Human, Mouse,Rat |
| Gene Name | AVIL |
| Protein Name | Advillin (p92) |
| Other Name | |
| Species | Human |
| Gene ID | 10677 |
| Uniprot | O75366, |
| Species.1 | Mouse |
| Gene ID.1 | 11567 |
| Uniprot.1 | O88398, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9WU06 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell junction, focal adhesion . Cell projection, neuron projection . Cell projection, axon . In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. . |
| Tissue Expression | Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus (PubMed:12034507). Expressed in podocytes (at protein level) (PubMed:29058690). |
| Signaling_pathway | |
| Research Areas | |
| Function | Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling . May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly . |
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