SKU: WP1133 Categories: ,

AGO3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1133-100
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Product details

Background:

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetAGO3
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)94kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityAGO3 Polyclonal Antibody detects endogenous levels of protein.
Gene NameEIF2C3 AGO3
Protein NameProtein argonaute-3 (Argonaute3) (hAgo3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Other Name
SpeciesHuman
Gene ID192669
UniprotQ9H9G7,
Species.1Mouse
Gene ID.1
Uniprot.1Q8CJF9
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm, P-body .
Tissue ExpressionPlacenta,Testis,
Signaling_pathway
Research Areas
FunctionFunction:Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.,similarity:Belongs to the argonaute family. Ago subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subunit:Interacts with EIF4B, IMP8, PRMT5 and TNRC6B.,
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